How to control spine density of neuron

Research group led by Professor Toshio Ohshima revealed that Cyclin-dependent kinase 5 (Cdk5) is important for the development and maintenance of the spines of the neurons, which has been reported in Cerebral Cortex. They further demonstrated that Cdk5 function is essential for synaptic transmission and spatial learning & memory under the collaboration with Itohara lab in RIKEN BSI, which has been reported in Mol Brain.

Cerebral Cortex
Molecular Brain

More information is available here (Japanese)